Just over a decade on from the action of 1999 teen sex comedy American Pie, the characters descend on their hometown East Great Falls, Michigan for their ten-year high school reunion. Over the course of a wild weekend, sparks fly as Jim (Jason Biggs), Stifler (Sean William Scott), Oz (Chris Klein) and Finch (Eddie Kaye Thomas) reconvene and reconnect. Jim and Michelle (Alyson Hannigan) are still married, but things get wobbly when their next door neighbour develops a crush on Jim. Meanwhile, Stifler, stuck in a dead-end temping job, is having a hard time with the ladies, Oz (Chris) has hit the big time after winning a TV talent show, and Finch is still hankering after Stifler's 'MILF' mother.