Sheldon and Leonard are brilliant physicists, living together in a technology-cluttered apartment, and spending their free time with a circle of fellow geeks from Cal Tech. Despite their hyper-intelligence they are hopelessly "backward" on a social level; after all, it isn't easy to pick up girls when the only things you know how to talk about are isotopes and video games. Our heroes have their world upturned when the incredibly beautiful and voluptuous Penny (Kaley Cuoco), a recent divorcee, moves into the apartment next door. Fascinated by the two "Beautiful Mind Guys", Penny decided to hang around with Sheldon and Leonard whenever possible. Having seldom been in such close proximity to a genuinely gorgeous girl, Leonard was anxious to make a few moves (assuming he knew any!), but Sheldon, perpetually unlucky in love, kept his distance, convinced that he'd only have his heart broken again. Occasionally dropping in for the random punchline were the boys' college pals, the loquacious Howard and the virtually mute Rajesh.