SYNECDOCHE, NEW YORK focuses on the wiles of Caden Cotard (Philip Seymour Hoffman), a regional theatre director who has won a MacArthur grant to help produce his next project. Cotard's artist wife, Adele Lack (Catherine Keener), subsequently departs with their daughter to Berlin, and he begins a flirtation with box office clerk Hazel (Samantha Morton). Much of the movie revolves around Cotard's ambitious next project, based around his life, which is being constructed in an enormous industrial space in New York City. As the years pass and the project is mired in endless rehearsals that replicate Cotard's existence, the tortured director obsesses over Adele, Hazel, his daughter, his health, and myriad other topics.