Slice-of-life comedy drama focusing on the efforts of two sisters to finally make a future for themselves. The future once looked bright for Rose Lorkowski (Amy Adams). At high school she led the cheerleading team and even dated the star quarterback. Now she's a thirty-something single mother, working every scrap of overtime she can in order to send her son to a better school. In the hope of raising more money, Rose persuades her stay-at-home sister Norah (Emily Blunt) to join forces with her on a new crime scene cleaning venture. As they start to get to grips with the aftermath of murders, suicides, and other messy situations, the sisters soon find their business growing, along with a generous helping of mutual respect and understanding.