Facing a slow and painful death unless given a life-saving serum, Michael Griffin (an invisible soldier gone rogue) hunts down Maggie Dalton, a beautiful, brilliant research biologist, who is the only person that can keep him alive. But when the government uses her as bait to trap Griffin, she turns to Frank Turner, a Seattle homicide detective, for protection. As Griffin becomes out-of-control, Turner's left with one choice to keep Maggie alive: he must take the invisibility serum and become a Hollow Man himself. The two Hollow Men face one another in a final battle.

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