A virus with no cure. A threat with no borders. A nation with no chance of escaping H5N1, the Avian Flu.

When a mutation of the virus is discovered in a local marketplace, China sends an emergency summons to Dr. Iris Varnack of the Epidemic Intelligence Service. When she arrives, she discovers her efforts may be too late - an American businessman has become the first victim of a strain that's passed from human to human.

As the flu begins its insidious spread, Secretary of Health and Human Services Collin Reed races to combat the ensuing chaos. The victim's wife, Denise Connelly, does what she can to help other infected people. It wasn't supposed to happen this way - until it did

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