Jackson (Morris Chestnut) is a successful pediatrician who is desperate for intimacy, but terrified of commitment. Brian (Bill Bellamy) is the sexy old-school bachelor who fights tooth and nail to protect his independence from women he thinks are undeserving of him. Terry (Shemar Moore) is a renowned womaniser who desperately wants to settle down. Derrick (D.L. Hughley) is a loving husband and father who always finds time for the boys, despite a demanding wife who refuses to meet his sexual demands. Denise (Gabrielle Union), Sheila (Tamala Jones), and Louise (Jennifer Lewis) are the "sisters" who teach them that the battle of the sexes is won in the heart in this brazenly comic look at love, honesty and the beauty of commitment.

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